Potential anticancer peptides design from the cysteine rich plant defensins: An in silico approach

Cancer is the second leading cause of mortality worldwide preceded by cardiovascular diseases. The therapeutic approaches for drug developmentinclude use small molecules, antibodies, peptidesor short nucleic acid sequences. peptide-based drugs have been developed to treat many diseases like diseases, cancer, metabolic disorders, immunological and viral infections. More than 80 peptide are already in market. These peptides several important benefits over antibodies proteins due their size, ease chemical synthesis further ability penetrate cell membrane. Furthermore, high specificity, activity, affinity. plant defensins BcDef1, TPP3, NaD1, 2N2R 2LR3 studied role wide range This study focussed on conformation rich disulfide bonds. structure BcDef1 has predicted from conformational ensemble. Then, we designed anticancer these with computational methods. immunogenicity as well homology human proteome. suggested interferon-gamma induction, later shown possess a very cancer.